N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine

Basic Information

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CAS Number

103478-62-2

Molecular Formula

C22H25NO4

Molecular Weight

367.45 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

111.0 to 115.0 deg-C

Boiling Point

537.3℃ at 760 mmHg

Density

1.194

Water Solubility

Slightly soluble in water.

Flash Point

278.7 °C

Refractive Index

1.581

Specific Rotation

-20.5 º (c=1% in DMF)

SMILES

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CC(C)CC(C(=O)O)N(C)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C22H25NO4/c1-14(2)12-20(21(24)25)23(3)22(26)27-13-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,14,19-20H,12-13H2,1-3H3,(H,24,25)/t20-/m0/s1

InChIKey

BUJQSIPFDWLNDC-FQEVSTJZSA-N

LogP

4.366600000000003

Topological Polar Surface Area

66.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

512

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

F1028
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-methylpentanoic acid
M03367
Fmoc-N-methyl-L-leucine
Fmoc-N-Me-L-Leu-OH
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-Leucine
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-4-methylpentanoic acid
SCHEMBL1486163
AKOS015837125
(2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-methyl-pentanoic acid;Fmoc-N-Me-Leu-OH
(2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-methyl-pentanoic acid
N-Fmoc-N-methyl-L-leucine
(2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-methylpentanoic acid
AM81898
DTXSID70426778
103478-62-2
EN300-1268400
Fmoc-N-Me-Leu-OH, >=99.0% (sum of enantiomers, HPLC)
AC-8569
MFCD00151933
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-leucine
HY-W008558
Fmoc-N-
Fmoc-N-Me-Leu-OH
A800747
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-alpha-methyl-L-leucine
Fmoc-N-a-methyl-L-Leucine
CS-W008558
L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-
FD21861
FMOC-MeLeu-OH

MDL Number

MFCD00151933

Customs Code

2924299090

FAQ

What regulatory guidelines apply to N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine (CAS: 103478-62-2)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine (CAS: 103478-62-2) is subject to regulation under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) for its hazardous properties. It is also covered by REACH regulations in the European Union, which mandate registration, evaluation, authorization, and restriction of chemicals. Additionally, the FDA and EPA may have specific requirements for its use and handling in the United States, particularly in pharmaceutical and industrial applications.

Are there alternatives to N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine in synthesis?

There are alternative reagents and approaches in the synthesis of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine. For instance, related fluorenylmethoxycarbonyl (Fmoc) protected amino acids can be used as precursors. Other alternatives include using different protecting groups or synthetic strategies that may offer better reactivity or yield in specific reaction conditions.

What is the market or research trend for N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine?

The market and research for N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine (CAS: 103478-62-2) is growing due to its importance in pharmaceutical and biotechnological applications. There is increasing interest in its use as a building block for peptide synthesis and drug discovery. Recent trends show a focus on developing more efficient and environmentally friendly synthesis methods and exploring its potential in novel therapeutic areas.

How should waste containing N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine (CAS: 103478-62-2) be handled?

Waste containing N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine (CAS: 103478-62-2) should be collected in appropriate containers and disposed of according to local regulations. Incineration is a common method for disposing of chemical waste, while professional waste disposal services can offer safe and compliant disposal options. It is important to follow all environmental protection precautions to minimize the impact on the environment and comply with safety requirements.