Leupeptin hemisulfate

Basic Information

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CAS Number

103476-89-7

Molecular Formula

C40H78N12O12S

Molecular Weight

951.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Density

1.2270

Solubility

H2O: 10 mM Solutions are stable for a week at 4 °C. Stock solutions are stable up to 6 months at −20?#x00b0;C.

Specific Rotation

-76 º (c=1, water)

SMILES

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CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O

InChI

InChI=1S/2C20H38N6O4.H2O4S/c2*1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;1-5(2,3)4/h2*11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H2,1,2,3,4)/t2*15-,16-,17-;/m00./s1

InChIKey

CIPMKIHUGVGQTG-VFFZMTJFSA-N

LogP

-1.0420000000000085

Topological Polar Surface Area

412.13999999999993 Å²

Hydrogen Bond Donor/Acceptor

16 / 24

Complexity

683

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt
Leupeptin hemisulfate anhydrous
UNII-05V9Y5208M
leupeptin sulfate
05V9Y5208M
L-Leucinamide, N-acetyl-L-leucyl-N-((1S)-4-((aminoiminomethyl)amino)-1-formylbutyl)-, sulfate (2:1)
Leupeptin hemisulfate
CHEMBL5187970
acetyl-leucyl-leucyl-arginal
Leupeptin, microbial, >=90% (HPLC)
Leupeptin, BioUltra, microbial, >=95% (HPLC)
A903394
Q27162636
Leupeptin hemisulfate salt
MFCD00037012
103476-89-7
(S)-2-Acetamido-N-((S)-1-(((S)-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide hemisulfate
EX-A4932
Leupeptin, synthetic, >=85% (HPLC)
Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate; Leupeptin hemisulfate salt
bis{N-acetyl-L-leucyl-N-[(2S)-5-{[azaniumyl(imino)methyl]amino}-1-oxopentan-2-yl]-L-leucinamide} sulfate
Leupeptin, Ac-Leu-Leu-argininal x 1/2 H2SO4, synthetic
Leupeptin, >4000 U/mg
AKOS024418728
N-acetyl-L-leucyl-N-[(2S)-5-carbamimidamido-1-oxopentan-2-yl]-L-leucinamide sulfate (2:1)
(2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide;sulfuric acid
Leupetin hemisulfate
BS-51398
[(4S)-4-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentyl]-(diaminomethylidene)azanium
CHEBI:90629
Leupeptin

MDL Number

MFCD00198027

Customs Code

29241900

FAQ

What is Leupeptin hemisulfate (CAS: 103476-89-7)?

Leupeptin hemisulfate is a synthetic compound with the chemical formula C16H25N5O4S. It is a serine protease inhibitor, commonly used in biochemical research. The compound is typically a white powder, slightly soluble in water, and has a molecular weight of approximately 411.5 g/mol. It is known for its stability under normal conditions and is often used as a protease inhibitor in laboratory settings.

What are the main uses of Leupeptin hemisulfate (CAS: 103476-89-7)?

Leupeptin hemisulfate is primarily used in pharmaceutical research as a protease inhibitor. It helps in studying enzyme activity and is also applied in biochemical assays to prevent unwanted proteolysis. Additionally, it is used in industrial and research applications for its ability to inhibit protein degradation, making it valuable in drug development and molecular biology experiments.

Is Leupeptin hemisulfate (CAS: 103476-89-7) safe?

Leupeptin hemisulfate is generally considered safe when handled properly, but it should be treated with caution. It is not classified as highly toxic, but skin contact and inhalation may cause irritation. Safety standards recommend using personal protective equipment (PPE) like gloves and goggles. Always follow standard laboratory safety protocols when working with this compound.

How should Leupeptin hemisulfate (CAS: 103476-89-7) be stored?

Leupeptin hemisulfate should be stored in a cool, dry place away from direct light. It is best kept in a sealed container at a temperature below 25°C and with low humidity to maintain stability. Avoid exposure to moisture and air to prevent degradation. Proper storage ensures its effectiveness and safety in research and industrial applications.