Losartan-d | CAS No. 1030937-27-9

Losartan-d

Basic Information

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CAS Number

1030937-27-9

Molecular Formula

C22H19ClD4N6O

Molecular Weight

426.94 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

184-190?C

SMILES

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CCCCc1nc(c(n1Cc1c([2H])c([2H])c(c(c1[2H])[2H])c1ccccc1c1n[nH]nn1)CO)Cl

InChI

InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)/i9D,10D,11D,12D

InChIKey

PSIFNNKUMBGKDQ-IRYCTXJYSA-N

LogP

4.266800000000004

Topological Polar Surface Area

92.51 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Synonyms & References

English

LOSARTAN-D4
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5yl)[1,1'-biphenyl-d4]-4-yl]Methyl]-1H-iMidazole-5-Methanol
Cozaar-d4
MK-954-d4
DuP-753 D4
Losartan d4
[2H4]-Losartan
1H-Imidazole-5-methanol,2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl-2,3,5,6-d4]methyl]
2-Butyl-4-chloro-1-[[2 inverted exclamation mark-(1H-tetrazol-5yl)[1,1 inverted exclamation mark-biphenyl-d4]-4-yl]methyl]-1H-imidazole-5-methanol
2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl-2,3,5,6-d4]methyl]-1H-imidazole-5-methanol
Losartan-d
(1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol

MDL Number

MFCD08063457

FAQ

What regulatory guidelines apply to Losartan-d (CAS: 1030937-27-9)?

Losartan-d (CAS: 1030937-27-9) is subject to various regulatory guidelines including the Globally Harmonized System (GHS) for classification and labeling of chemicals, REACH regulations for European Union, and FDA and EPA guidelines in the United States. These guidelines cover safety data sheets (SDS), hazard communication, and environmental and occupational health and safety standards.

Are there alternatives to Losartan-d in synthesis?

Yes, there are several alternatives to Losartan-d in synthesis. Common alternatives include other angiotensin II receptor blockers such as valsartan and irbesartan. These alternatives can be used as starting materials or intermediates, providing similar or enhanced properties depending on the specific synthesis route.

What is the market or research trend for Losartan-d (CAS: 1030937-27-9)?

The market for Losartan-d (CAS: 1030937-27-9) is closely tied to its use in pharmaceutical research and development, particularly in hypertension and cardiovascular disease treatments. Research trends focus on understanding its therapeutic efficacy, potential side effects, and comparing it with existing angiotensin II receptor blockers. Market demand is also influenced by regulatory approvals and clinical trial outcomes.

How should waste containing Losartan-d (CAS: 1030937-27-9) be handled?

Waste containing Losartan-d (CAS: 1030937-27-9) should be collected in appropriate containers and disposed of in accordance with local and national regulations. Incineration is a common method for waste disposal, and professional waste disposal services are recommended for handling hazardous waste. Environmental protection should be a priority, ensuring that all disposal methods comply with safety and environmental standards to prevent contamination of soil and water sources.