Daptomycin | CAS No. 103060-53-3

Daptomycin

Basic Information

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CAS Number

103060-53-3

Molecular Formula

C72H101N17O26

Molecular Weight

1620.7 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

202-204°C

Boiling Point

2078.2°C at 760 mmHg

Flash Point

87℃

Solubility

methanol: soluble5mg/mL

SMILES

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CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C

InChI

InChI=1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45-,46+,47+,48+,49+,50-,60+,61+/m1/s1

InChIKey

DOAKLVKFURWEDJ-QCMAZARJSA-N

LogP

0.88280

Complexity

3480

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 i.v. in mice: 600 mg/kg (Debono)

Synonyms & References

English

DAPTOMYCIN [VANDF]
DAPTOMYCIN
DAPTOMYCIN [USAN]
(2R)-daptomycin
N-(Decanoyl)-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-(3R)-3-methyl-L-glutamyl-3-(2-aminobenzoyl)-L-alanine 1.13->3.4-lactone
DTXSID1041009
NWQ5N31VKK
SCHEMBL13491700
103060-53-3
J01XX09
DAPTOMYCIN IN 0.9% SODIUM CHLORIDE
LY 146032
DAPTOMYCIN [JAN]
Cubicin Rf
EX-A1967
N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
Deptomycin
Daptomicina
DAPTOMYCIN [MI]
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
DAPTOMYCIN [WHO-DD]
Cubicin (TN)
DTXCID9021009
Cidecin
Daptomycinum [Latin]
Daptomycin for injection
DAPZURA RT
Daptomycine
Daptomycin (JAN/USAN/INN)
Cubicin
CS-1857

MDL Number

MFCD08282794

FAQ

What is Daptomycin (CAS: 103060-53-3)?

Daptomycin is an antibiotic belonging to the lipopeptide class. It has the chemical formula C48H82N10O12 and is known for its ability to disrupt bacterial cell membranes. It is effective against a range of Gram-positive bacteria and is commonly used in clinical settings for treating infections.

What are the main uses of Daptomycin (CAS: 103060-53-3)?

Daptomycin is primarily used in pharmaceuticals to treat severe skin infections and bloodstream infections caused by Gram-positive bacteria. It is also used in research for studying antibiotic mechanisms and in veterinary medicine for treating bacterial infections in livestock.

Is Daptomycin (CAS: 103060-53-3) safe?

Daptomycin is generally considered safe when used as directed, but it may cause side effects such as muscle pain or gastrointestinal issues. Proper handling and adherence to safety guidelines are essential to minimize risks. It is approved by regulatory bodies for its therapeutic use.

How should Daptomycin (CAS: 103060-53-3) be stored?

Daptomycin should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 2°C to 8°C and requires protection from moisture. Always store in a sealed container to maintain stability and potency.