5-Methoxy-1,2,3,4-tetrahydroisoquinoline | CAS No. 103030-70-2

5-Methoxy-1,2,3,4-tetrahydroisoquinoline

Basic Information

CAS Number

103030-70-2

Molecular Formula

C10H13NO

Molecular Weight

163.22 g/mol

AD

Basic Physical Properties

COc1cccc2CNCCc12

InChI

InChI=1S/C10H13NO/c1-12-10-4-2-3-8-7-11-6-5-9(8)10/h2-4,11H,5-7H2,1H3

InChIKey

MCJYXDLWQYGCIQ-UHFFFAOYSA-N

LogP

1.3409

Topological Polar Surface Area

21.259999999999998 Ų

Hydrogen Bond Donor/Acceptor

1 / 2

Synonyms & References

English

  • 5-Methoxy-1,2,3,4-tetrahydroisoquinoline
  • 1,2,3,4-tetrahydro-5-methoxyIsoquinoline
  • 5‐METHOXY‐1,2,3,4‐TETRAHYDROISOQUINOLINE
  • 5-Methoxy-1,2,3,4-tetrahydro-isochinolin
  • 5-methoxy-1,2,3,4-tetrahydro-isoquinoline
  • ACT10838
  • AGN-PC-00OG8B
  • CHEBI:211829
  • CHEMBL70546
  • SureCN2358135
  • m90106
  • Isoquinoline, 1,2,3,4-tetrahydro-5-Methoxy-

MDL Number

MFCD08544280

FAQ

What are the physical and chemical properties of 5-Methoxy-1,2,3,4-tetrahydroisoquinoline (CAS: 103030-70-2)?

5-Methoxy-1,2,3,4-tetrahydroisoquinoline is a white or off-white solid with a molecular weight of approximately 183.23 g/mol. It is slightly soluble in water but soluble in organic solvents like methanol and ethanol. This compound is relatively stable under normal conditions but can react with strong acids to form methanol and 1,2,3,4-tetrahydroisoquinoline. It is a key intermediate in the synthesis of various pharmaceuticals and natural products.

How is 5-Methoxy-1,2,3,4-tetrahydroisoquinoline (CAS: 103030-70-2) typically synthesized?

5-Methoxy-1,2,3,4-tetrahydroisoquinoline is commonly synthesized by the methylation of 1,2,3,4-tetrahydroisoquinoline using methanol in the presence of a strong acid like hydrochloric acid. The reaction typically proceeds with high selectivity and moderate to good yield. Other methods include the reduction of 5-methoxymethylisoquinoline to form the desired tetrahydro derivative.

What industries use 5-Methoxy-1,2,3,4-tetrahydroisoquinoline (CAS: 103030-70-2)?

5-Methoxy-1,2,3,4-tetrahydroisoquinoline is widely used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also utilized in the production of natural product analogs, and can be found in certain polymers and sensors due to its unique chemical structure.

What precautions should be taken when handling 5-Methoxy-1,2,3,4-tetrahydroisoquinoline (CAS: 103030-70-2)?

When handling 5-Methoxy-1,2,3,4-tetrahydroisoquinoline, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be handled with care, and spills should be cleaned up using appropriate chemical spill kits. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.

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