Capmatinib | CAS No. 1029712-80-8

Capmatinib

Basic Information

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CAS Number

1029712-80-8

Molecular Formula

C23H17FN6O

Molecular Weight

412.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F

InChI

InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)

InChIKey

LIOLIMKSCNQPLV-UHFFFAOYSA-N

LogP

3.429000000000001

Topological Polar Surface Area

85.07000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

637

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

INCB28060
1 week
2-Fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
Capmatinib
Capmatinib (INCB28060)
inc280
INCB28060(Capmatinib)
BenzaMide
INCB280
2-fluoro-N-methyl-4-[(7-quinolin-6-ylmethyl)imidazo[1,2-b]triazin-2-yl]benzamide
2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazolo[1,2-b][1,2,4]triazin-2-yl]benzamide
INC-280
INCB-28060
QC-7530
UNII-TY34L4F9OZ
NC280
INC28060
INCB028060
NVP-INC280
BenzaMide HCl
INCB28060, INC280
INC 280 (INCB28060)
TY34L4F9OZ
INCB 28060
2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide
BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-
C2
Tabrecta
2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]tr

MDL Number

MFCD18633285

FAQ

What is Capmatinib (CAS: 1029712-80-8)?

Capmatinib is a small molecule tyrosine kinase inhibitor. It has the chemical formula C20H19FN5O2. Capmatinib selectively targets the MET receptor tyrosine kinase, which is overexpressed in certain cancers.

What are the main uses of Capmatinib (CAS: 1029712-80-8)?

Capmatinib is primarily used in the treatment of non-small cell lung cancer (NSCLC) with MET exon 14 skipping mutations. It is also being studied for its potential use in other cancers.

Is Capmatinib (CAS: 1029712-80-8) safe?

Capmatinib is generally safe when used as directed. However, it can cause side effects such as diarrhea, fatigue, and nausea. Patients should be monitored for these effects and other potential issues. Proper handling and storage are essential to avoid exposure risks.

How should Capmatinib (CAS: 1029712-80-8) be stored?

Capmatinib should be stored at room temperature, between 15-30°C (59-86°F), in a tightly sealed container. Avoid exposure to moisture and light. Keep out of reach of children and ensure it is stored in a secure location.