tert-Butyl ceftazidime

Basic Information

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CAS Number

102772-66-7

Molecular Formula

C26H30N6O7S2

Molecular Weight

602.68 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)(C)OC(=O)C(C)(C)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-]

InChI

InChI=1S/C26H30N6O7S2/c1-25(2,3)38-23(37)26(4,5)39-30-16(15-13-41-24(27)28-15)19(33)29-17-20(34)32-18(22(35)36)14(12-40-21(17)32)11-31-9-7-6-8-10-31/h6-10,13,17,21H,11-12H2,1-5H3,(H3-,27,28,29,33,35,36)/b30-16-/t17-,21-/m1/s1

InChIKey

KRTGQDGIPNXUGP-ZLQBWVSZSA-N

LogP

0.66620

Complexity

1130

Synonyms & References

English

Ceftazidime t-Butyl Ester
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
1-[[(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium inner salt
Ceftazidime Ep Impurity E
Ceftazidime tert-butyl ester
Ceftazidime Impurity E (EP) (Ceftazidime t-Butyl Ester )
(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Ceftazidime Impurity E
SCHEMBL9640914
31XYW5AKQK
CEFTAZIDIME PENTAHYDRATE IMPURITY E [EP IMPURITY]
tert-Butyl ceftazidime
(6R,7R)-7-[[(2Z)-2-(2-aminothiazol-4-yl)-2-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-8-oxo-3-[(pyridin-1-ium-1-yl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,
102772-66-7
1-[[(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium Inner Salt
UNII-31XYW5AKQK
Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt

MDL Number

MFCD21363485

FAQ

What regulatory guidelines apply to tert-Butyl ceftazidime (CAS: 102772-66-7)?

Regulatory guidelines for tert-Butyl ceftazidime (CAS: 102772-66-7) include OSHA, EPA, and FDA regulations. It must comply with the REACH regulations in the EU. This antibiotic is subject to GHS classification, which includes labeling requirements for health hazards. Additionally, it requires proper documentation and handling as per local and international pharmaceutical regulations.

Are there alternatives to tert-Butyl ceftazidime (CAS: 102772-66-7) in synthesis?

Alternatives to tert-Butyl ceftazidime (CAS: 102772-66-7) in synthesis include other beta-lactam antibiotics such as ceftazidime and its derivatives. Common alternatives include using different protecting groups or varying reaction conditions. Isomers and analogs may also be explored to achieve similar antimicrobial properties with potentially better pharmacokinetic profiles.

What is the market or research trend for tert-Butyl ceftazidime (CAS: 102772-66-7)?

The market for tert-Butyl ceftazidime (CAS: 102772-66-7) is driven by increasing antibiotic resistance and the need for effective antimicrobial agents. Research trends focus on improving its efficacy, reducing side effects, and exploring new formulations. There is also growing interest in developing second and third-generation cephalosporins, which may include variations or derivatives of ceftazidime like tert-Butyl ceftazidime.

How should waste containing tert-Butyl ceftazidime (CAS: 102772-66-7) be handled?

Waste containing tert-Butyl ceftazidime (CAS: 102772-66-7) should be managed according to regulatory requirements. It is advisable to collect and store the waste in a sealed container, ensuring it is labeled appropriately. Incineration or professional waste disposal services should be used to ensure proper disposal. Environmental protection measures include minimizing water contamination and following local waste management guidelines to prevent ecological harm.