Aciclovir (Acyclovir) EP Impurity A (Acyclovir USP Related Compound A)

Basic Information

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CAS Number

102728-64-3

Molecular Formula

C10H13N5O4

Molecular Weight

267.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

242 ºC

SMILES

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CC(=O)OCCOCN1C=NC2=C1N=C(NC2=O)N

InChI

InChI=1S/C10H13N5O4/c1-6(16)19-3-2-18-5-15-4-12-7-8(15)13-10(11)14-9(7)17/h4H,2-3,5H2,1H3,(H3,11,13,14,17)

InChIKey

DMHAXLGAKQREIL-UHFFFAOYSA-N

LogP

-0.7609999999999995

Topological Polar Surface Area

125.12 Å²

Hydrogen Bond Donor/Acceptor

3 / 9

Complexity

399

Safety Information

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GHS Hazard Pictograms

H341

Hazard Statement

H341 Suspected of causing genetic defects
Germ cell mutagenicity

Synonyms & References

English

DODECYLBORICACID
9-(2-acetoxyethoxy methyl) guanine
SCHEMBL7814355
CS-0260655
VALACICLOVIR HYDROCHLORIDE IMPURITY I [EP IMPURITY]
Acyclovir Acetate
FT-0642497
F83375
AMY17855
9-(2-Acetoxyethoxymethyl)guanine
Q27294126
2-[(2-amino-6-oxo-6,9-dihydro-1h-purin-9-yl)methoxy]ethyl acetate
DMHAXLGAKQREIL-UHFFFAOYSA-N
6H-Purin-6-one, 9-((2-(acetyloxy)ethoxy)methyl)-2-amino-1,9-dihydro-
Aciclovir impurity A [EP]
BCP27790
VALACICLOVIR HYDROCHLORIDE HYDRATE IMPURITY I [EP IMPURITY]
9-(2-acetoxyethoxy)methylguanine
SR-01000401987-1
UNII-Y16CE349S3
9-(2'-ACETOXYETHOXYMETHYL)-GUANINE
102728-64-3
SR-01000401987
2-((2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)ethyl acetate
EN300-755304
9-(2-acetyloxyethoxymethyl)guanine
Z2025567901
2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl Acetate
2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl acetate, pharmaceutical impurity standard
2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl acetate
2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl acetate

MDL Number

MFCD00871663

FAQ

What are the physical and chemical properties of Aciclovir (Acyclovir USP Related Compound A) (CAS: 102728-64-3)?

Aciclovir USP Related Compound A (CAS: 102728-64-3) is a crystalline compound with a molecular weight of approximately 225.22 g/mol. It is slightly soluble in water and ethanol. The compound is relatively stable under normal conditions but may react with strong acids or bases.

How is Aciclovir USP Related Compound A (CAS: 102728-64-3) typically synthesized?

Aciclovir USP Related Compound A (CAS: 102728-64-3) is synthesized through a multi-step process involving the condensation of 2-amino-6-hydroxy-9-(2-hydroxyethoxy)methylpurine and 1,3-propanediol. The synthesis typically requires careful control of reaction conditions, with the use of various catalysts and solvents to achieve high yields and selectivity.

What industries use Aciclovir USP Related Compound A (CAS: 102728-64-3)?

Aciclovir USP Related Compound A (CAS: 102728-64-3) is primarily used in the pharmaceutical industry, particularly in the production of antiviral drugs. It is also used in research and development for the evaluation of drug candidates and as a reference compound in quality control processes.

What precautions should be taken when handling Aciclovir USP Related Compound A (CAS: 102728-64-3)?

When handling Aciclovir USP Related Compound A (CAS: 102728-64-3), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled carefully, using appropriate safety protocols, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.