5-Iodouridine | CAS No. 1024-99-3

5-Iodouridine

Basic Information

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CAS Number

1024-99-3

Molecular Formula

C9H11IN2O6

Molecular Weight

370.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

205-207 °C (dec.)

Water Solubility

Soluble in water.

SMILES

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C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)O)I

InChI

InChI=1S/C9H11IN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1

InChIKey

RKSLVDIXBGWPIS-UAKXSSHOSA-N

LogP

-2.2473

Topological Polar Surface Area

124.77999999999997 Å²

Hydrogen Bond Donor/Acceptor

4 / 8

Complexity

414

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

photolabile

Synonyms & References

English

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione
5-Iodouridine, 95%
EN300-221745
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dione;NSC 523375; AC1L5TPI
NS00042629
EINECS 213-833-1
NSC 523375
SCHEMBL97335
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
CHEMBL3249838
5-Iodouridine
MFCD00006532
1-((2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL)-5-IODO-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE
1-(3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-5-IODOPYRIMIDINE-2,4(1H,3H)-DIONE
YZK4KVC76P
AKOS015896912
C9H11IN2O6
Z2197277787
1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodopyrimidine-2,4(1H,3H)-dione
1024-99-3
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione
UNII-YZK4KVC76P
AMY40627
F12678
5-Iodouridine, >=97.0% (HPLC)
2,4-Dihydroxy-5-iodo-1-beta-D-ribofuranosylpyrimidine
AC-32308
Uridine, 5-iodo-
NSC-523375
A800578
DS-10692

MDL Number

MFCD00006532

Customs Code

2934999090

FAQ

What regulatory guidelines apply to 5-Iodouridine (CAS: 1024-99-3)?

5-Iodouridine (CAS: 1024-99-3) falls under the scope of the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) for hazardous substances. It is also regulated under the REACH regulations in the European Union, which requires manufacturers and importers to register chemical substances and provide safety information. In the United States, the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA) have specific guidelines and requirements for handling and using this compound. Detailed MSDS sheets and safety data are essential for compliance.

Are there alternatives to 5-Iodouridine (CAS: 1024-99-3) in synthesis?

While 5-Iodouridine is a specific compound, there are alternative reagents that can be used in similar synthetic processes. For instance, 5-Bromouridine can be a suitable alternative due to the similarity in structural properties. Other alternatives include 5-Chlorouridine and 5-Fluorouridine, depending on the specific requirements of the synthesis. It is important to evaluate the biological activity and cost-effectiveness of each alternative.

What is the market or research trend for 5-Iodouridine (CAS: 1024-99-3)?

The market for 5-Iodouridine (CAS: 1024-99-3) is primarily driven by its application in research, particularly in nucleotide chemistry and molecular biology. Recent research trends have shown an increasing interest in developing iodinated nucleosides for therapeutic and diagnostic applications. The demand is expected to grow as more studies explore the unique properties of iodine in modifying the biological activity of nucleosides. The price trend for 5-Iodouridine is generally stable, with slight fluctuations due to supply and demand factors.

How should waste containing 5-Iodouridine (CAS: 1024-99-3) be handled?

Waste containing 5-Iodouridine (CAS: 1024-99-3) should be collected in suitable, labeled containers and stored in a secure location to prevent spillage or contamination. The waste should be treated through incineration or professional waste disposal services that comply with environmental regulations. Proper personal protective equipment (PPE) should be used during handling to ensure safety. It is crucial to follow local and national regulations for the disposal of hazardous chemicals to minimize environmental impact and ensure worker safety.