5-Chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide

Basic Information

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CAS Number

10238-21-8

Molecular Formula

C23H28ClN3O5S

Molecular Weight

494.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

Melting Point

172.0 to 176.0 deg-C

Water Solubility

Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.

Solubility

ethanol: soluble2mg/mL

Refractive Index

1.6100 (estimate)

SMILES

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COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

InChI

InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)

InChIKey

ZNNLBTZKUZBEKO-UHFFFAOYSA-N

LogP

3.641700000000002

pKa

5.3(at 25℃)

Topological Polar Surface Area

113.6 Å²

Hydrogen Bond Donor/Acceptor

3 / 8

Complexity

746

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 in rats and mice (g/kg): >20 orally; >12.5 i.p.; >20 s.c. (Mizukami)

Synonyms & References

English

Abbenclamide
Glynase (TN)
Glibenclamide - Bio-X
W-108874
1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea
NCGC00015467-37
S1716
5-Chloro-N-(2-[4-(([(cyclohexylamino)carbonyl]amino)sulfonyl)phenyl]ethyl)-2-methoxybenzamide #
Lederglib
NSC-813214
LP00499
EINECS 233-570-6
Glibenclamid Basics
Z277540138
NCGC00023447-07
DivK1c_000481
SR-01000000196-8
Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl-
GLUCOVANCE COMPONENT GLYBURIDE
Duraglucon
NSC813214
Prestwick2_000316
Yuglucon
Glibenclamid Fabra
Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
Tox21_110158_1
Pharmakon1600-02300229
RP-1127
Glibenclamide for peak identification, European Pharmacopoeia (EP) Reference Standard
SR-01000000196-6
SR-01000000196

MDL Number

MFCD00056625

Customs Code

2935009090

FAQ

What is 5-Chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (CAS: 10238-21-8)?

5-Chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide is a synthetic organic compound with the CAS number 10238-21-8. It is characterized by its complex structure, which includes a benzamide group substituted with a methoxy group and a chloro group, as well as a sulfamoyl group attached to a cyclohexylcarbamoyl moiety. This compound is known for its potential applications in pharmaceutical research due to its structural versatility and reactivity.

What are the main uses of 5-Chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (CAS: 10238-21-8)?

The primary use of 5-Chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (CAS: 10238-21-8) is in pharmaceutical research, particularly as a potential lead compound for drug development. It may also find applications in chemical synthesis and as an intermediate in the production of various organic compounds. Due to its complex structure, it is of interest in medicinal chemistry for its possible biological activities.

Is 5-Chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (CAS: 10238-21-8) safe?

The safety of 5-Chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (CAS: 10238-21-8) depends on its handling and application. As a chemical compound, it should be treated with care, following standard laboratory safety protocols. Precautions include using protective gloves, goggles, and ensuring proper ventilation. It is not classified as highly toxic, but its potential health effects require further study, and it should be handled in accordance with OSHA and EPA guidelines.

How should 5-Chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (CAS: 10238-21-8) be stored?

5-Chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (CAS: 10238-21-8) should be stored in a cool, dry, and dark place, preferably at a temperature below 25°C. It is sensitive to moisture and light, so it should be kept in a sealed container and protected from exposure. Storage in a well-ventilated area is recommended to ensure stability and prevent degradation.