Lomerizine hydrochloride

Basic Information

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CAS Number

101477-54-7

Molecular Formula

C27H32Cl2F2N2O3

Molecular Weight

541.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

No data available

Melting Point

214-218°C dec.

Boiling Point

527.3°C at 760 mmHg

Solubility

DMSO: ≥30mg/mL

SMILES

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COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC.Cl.Cl

InChI

InChI=1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H

InChIKey

LOGVKVSFYBBUAJ-UHFFFAOYSA-N

LogP

5.741400000000007

Topological Polar Surface Area

34.17 Å²

Hydrogen Bond Donor/Acceptor

0 / 5

Complexity

568

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H360 May damage fertility or the unborn child
Reproductive toxicity

H362 May cause harm to breast-fed children
Reproductive toxicity, effects on or via lactation

Toxicity

LD50 orally in mice: 300 mg/kg (Ohtaka)

Synonyms & References

English

1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine Hydrochloride Terranas Migsis
HY-B0768A
Lomerizine dihydrochloride
1-[BIS(4-FLUOROPHENYL)METHYL]-4-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE
NCGC00164543-01
SCHEMBL1153647
3W473D5LIY
DE-090
Tox21_112172_1
Terranas
SW197640-2
101477-54-7
CCG-269965
Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)-, dihydrochloride
CHEMBL2356978
Q27258118
1-(2,3,4-Trimethoxybenzyl)-4-(bis(4-fluorophenyl)methyl)piperazine dihydrochloride
CAS-101477-54-7
s4084
101477-54-7, 101477-55-8(free base)
LOMERIZINE HYDROCHLORIDE [WHO-DD]
AKOS015900365
J-000407
Lomerizine dihydrochloride, >=98% (HPLC), powder
MFCD01703867
1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride
Lomerizine hydrochloride (JAN)
1-(bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
LOMERIZINE DIHYDROCHLORIDE [MI]
AS-74676
FT-0627971

MDL Number

MFCD01703867

FAQ

What is Lomerizine hydrochloride (CAS: 101477-54-7)?

Lomerizine hydrochloride (CAS: 101477-54-7) is a centrally acting antihypertensive agent with dihydropyridine calcium channel antagonist properties. It is used in the treatment of essential hypertension.

What are the main uses of Lomerizine hydrochloride (CAS: 101477-54-7)?

Lomerizine hydrochloride (CAS: 101477-54-7) is primarily used as an antihypertensive agent in the management of essential hypertension. It is available as a tablet and is prescribed by healthcare professionals to lower blood pressure.

Is Lomerizine hydrochloride (CAS: 101477-54-7) safe?

Lomerizine hydrochloride (CAS: 101477-54-7) is generally considered safe when used as directed. However, it is important to follow the dosing instructions provided by a healthcare professional and take precautions such as avoiding driving or operating heavy machinery due to potential dizziness or drowsiness.

How should Lomerizine hydrochloride (CAS: 101477-54-7) be stored?

Lomerizine hydrochloride (CAS: 101477-54-7) should be stored at room temperature, between 15°C and 30°C (59°F and 86°F), in a tightly closed container. It should be protected from moisture and light. Avoid storing it in high humidity or direct sunlight.