How is 4,6-Dichloroquinoline-3-carbonitrile (CAS: 936498-04-3) typically synthesized?

4,6-Dichloroquinoline-3-carbonitrile (CAS: 936498-04-3) is typically synthesized via electrophilic aromatic substitution reactions. Common methods involve the chlorination of quinoline followed by nitrilization with phosphorus oxychloride. The reaction often requires a solvent like acetonitrile and is conducted under mild to moderate conditions. The yield and selectivity are generally good, with the product being isolated by recrystallization.