Compound Q&A
How is 3-Methoxy-2,4,6-trifluorobenzoic acid (CAS: 886499-94-1) typically synthesized?
Answer
3-Methoxy-2,4,6-trifluorobenzoic acid is typically synthesized via the Friedel-Crafts alkylation of 2,4,6-trifluorobenzoic anhydride with methanol. This process requires strong Lewis acids like aluminum chloride as a catalyst. The reaction is carried out at low temperatures to achieve a good yield. The product is isolated by recrystallization from solvents like dichloromethane.
About
CAS No
886499-94-1
English Name
3-Methoxy-2,4,6-trifluorobenzoic acid
Molecular Formula
C8H5F3O3
Molecular Weight
206.12 g/mol
SMILES
COC1=C(C=C(C(=C1F)C(=O)O)F)F
InChIKey
HBJGDRQQDGUBGN-UHFFFAOYSA-N
Last Updated: 2026-04-01 14:15
