Compound Q&A
How is (R)-2-Amino-2-(2,3-dihydro-1H-inden-2-yl)acetic acid (CAS: 181227-46-3) typically synthesized?
Answer
(R)-2-Amino-2-(2,3-dihydro-1H-inden-2-yl)acetic acid can be synthesized through a multi-step process involving the condensation of 2,3-dihydro-1H-inden-2-one with an amine, followed by reduction and acetylation. Key steps include the use of a chiral auxiliary for the stereoselective formation of the amino group. The overall yield is around 70%, and selectivity is high due to the use of chiral catalysts and reagents.
About
CAS No
181227-46-3
English Name
(R)-2-Amino-2-(2,3-dihydro-1H-inden-2-yl)acetic acid
Molecular Formula
C11H13NO2
Molecular Weight
191.23 g/mol
SMILES
C1C(CC2=CC=CC=C21)C(C(=O)O)N
InChIKey
GUDHMDVRURNAHL-SNVBAGLBSA-N
Last Updated: 2026-01-04 19:14
