(R)-2-Amino-2-(2,3-dihydro-1H-inden-2-yl)acetic acid(CAS: 181227-46-3)

(R)-2-Amino-2-(2,3-dihydro-1H-inden-2-yl)acetic acid is a chiral compound with a molecular weight of approximately 222.26 g/mol. It exists in a crystalline form with a melting point of around 175-178°C. The compound has a basic character due to its amine group, with a pKa close to 9.9. It is moderately soluble in water and organic solvents such as ethanol and acetone. Chemically, it reacts readily with acids to form salts and is stable under mild conditions but should be protected from strong oxidizing agents.

(R)-2-Amino-2-(2,3-dihydro-1H-inden-2-yl)acetic acid can be synthesized through a multi-step process involving the condensation of 2,3-dihydro-1H-inden-2-one with an amine, followed by reduction and acetylation. Key steps include the use of a chiral auxiliary for the stereoselective formation of the amino group. The overall yield is around 70%, and selectivity is high due to the use of chiral catalysts and reagents.

(R)-2-Amino-2-(2,3-dihydro-1H-inden-2-yl)acetic acid is primarily used in the pharmaceutical industry for the synthesis of biologically active compounds. It also finds applications in polymer science for the development of functional materials and in the electronics industry for semiconductor fabrication. Additionally, it is used in the production of sensors and other advanced materials.

When handling (R)-2-Amino-2-(2,3-dihydro-1H-inden-2-yl)acetic acid, it is important to wear appropriate personal protective equipment (PPE) including gloves, lab coat, and safety goggles. The compound should be stored in a cool, well-ventilated area away from strong acids and oxidizers. Fume hoods should be used during operations to minimize inhalation risk. In case of a spill, avoid contact with skin and eyes, and clean up with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.