Compound Q&A
How is 2,6-Dichloro-4-(trifluoromethyl)nicotinic acid (CAS: 503437-19-2) typically synthesized?
Answer
2,6-Dichloro-4-(trifluoromethyl)nicotinic acid is typically synthesized via the condensation of 2,6-dichloropyridine with trifluoroacetyl chloride. The reaction is usually carried out in the presence of a base like pyridine to improve the yield. The product is then isolated and purified through recrystallization. Detailed conditions and catalysts are crucial for achieving the desired selectivity and high yield.
About
CAS No
503437-19-2
English Name
2,6-Dichloro-4-(trifluoromethyl)nicotinic acid
Molecular Formula
C7H2Cl2F3NO2
Molecular Weight
259.998 g/mol
SMILES
O=C(O)C1=C(Cl)N=C(Cl)C=C1C(F)(F)F
InChIKey
PZBCYMXYIZQNFE-UHFFFAOYSA-N
Last Updated: 2026-01-04 19:14
