Compound Q&A
How is 1-(7-methoxy-4-quinolyl)-3-[6-(trifluoromethyl)-2-pyridyl]urea (CAS: 1384424-80-9) typically synthesized?
Answer
![1-(7-methoxy-4-quinolyl)-3-[6-(trifluoromethyl)-2-pyridyl]urea](https://static.chemtradehub.com/structs/138/1384424-80-9-cc5b.webp "1-(7-methoxy-4-quinolyl)-3-[6-(trifluoromethyl)-2-pyridyl]urea")
1-(7-methoxy-4-quinolyl)-3-[6-(trifluoromethyl)-2-pyridyl]urea can be synthesized by reacting 7-methoxy-4-quinoline with 6-(trifluoromethyl)-2-pyridine in the presence of a base like potassium carbonate. The reaction mixture is typically heated in an inert solvent such as N,N-dimethylformamide (DMF) at elevated temperatures. The yield is generally around 70-80%, and the product is purified via recrystallization from a suitable solvent.
About
CAS No
1384424-80-9
English Name
1-(7-methoxy-4-quinolyl)-3-[6-(trifluoromethyl)-2-pyridyl]urea
Molecular Formula
C17H13F3N4O2
Molecular Weight
362.31 g/mol
SMILES
COc1ccc2c(c1)nccc2NC(=O)Nc1cccc(n1)C(F)(F)F
InChIKey
VQPBIJGXSXEOCU-UHFFFAOYSA-N
Last Updated: 2026-01-01 15:34
![1-(7-methoxy-4-quinolyl)-3-[6-(trifluoromethyl)-2-pyridyl]urea — Shanghai Jixiang Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce6f4d2b2de6e8e95a45bf/67ce6f4d2b2de6e8e95a45bf-logo.webp){kind=logo}