Compound Q&A
How is [3-(Trifluoromethyl)phenyl]methanesulfonyl chloride (CAS: 127162-96-3) typically synthesized?
Answer
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[3-(Trifluoromethyl)phenyl]methanesulfonyl chloride is synthesized through the reaction of 3-(trifluoromethyl)phenylmethanol with methanesulfonyl chloride in the presence of a base like triethylamine. The reaction is typically carried out in an anhydrous organic solvent like dichloromethane. The yield is generally high, and the product can be isolated by filtration and recrystallization. The reaction is highly selective and proceeds with good regiochemical control.
About
CAS No
127162-96-3
English Name
[3-(Trifluoromethyl)phenyl]methanesulfonyl chloride
Molecular Formula
C8H6ClF3O2S
Molecular Weight
258.65 g/mol
SMILES
C1=CC(=CC(=C1)C(F)(F)F)CS(=O)(=O)Cl
InChIKey
WIGCBGFBBRJTLS-UHFFFAOYSA-N
Last Updated: 2025-11-28 19:29
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