Compound Q&A
How is [3-(Benzyloxy)-5-fluorophenyl]boronic acid (CAS: 850589-56-9) typically synthesized?
Answer
![[3-(Benzyloxy)-5-fluorophenyl]boronic acid](https://static.chemtradehub.com/structs/850/850589-56-9-16e5.webp "[3-(Benzyloxy)-5-fluorophenyl]boronic acid")
[3-(Benzyloxy)-5-fluorophenyl]boronic acid is typically synthesized via a Suzuki coupling reaction. A fluoroaromatic aldehyde is reacted with a benzyloxyboronic acid pinacol ester in the presence of a palladium catalyst, a base, and a ligand. The yield is generally high, and the method is known for its high regioselectivity and stereoselectivity.
About
CAS No
850589-56-9
English Name
[3-(Benzyloxy)-5-fluorophenyl]boronic acid
Molecular Formula
C13H12BFO3
Molecular Weight
246.05 g/mol
SMILES
Fc1cc(OCc2ccccc2)cc(c1)B(O)O
InChIKey
QQOFKMPPQQMUDH-UHFFFAOYSA-N
Last Updated: 2025-10-29 13:16
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