[3-(Benzyloxy)-5-fluorophenyl]boronic acid(CAS: 850589-56-9)

[3-(Benzyloxy)-5-fluorophenyl]boronic acid is a solid with a crystalline form. Its molecular weight is approximately 272.24 g/mol. It has a low solubility in water but is soluble in organic solvents such as dichloromethane and dimethylformamide. It is an electrophilic reagent and shows reactivity towards nucleophiles, especially in the presence of a catalyst such as Pd(0).

[3-(Benzyloxy)-5-fluorophenyl]boronic acid is typically synthesized via a Suzuki coupling reaction. A fluoroaromatic aldehyde is reacted with a benzyloxyboronic acid pinacol ester in the presence of a palladium catalyst, a base, and a ligand. The yield is generally high, and the method is known for its high regioselectivity and stereoselectivity.

[3-(Benzyloxy)-5-fluorophenyl]boronic acid finds applications in the pharmaceutical industry for the synthesis of drug intermediates. It is also used in the polymer industry for the modification of polymer structures and in the semiconductor industry for the production of organic semiconductors.

When handling [3-(Benzyloxy)-5-fluorophenyl]boronic acid, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Refer to the safety data sheet (SDS) for detailed handling and disposal information.