How is 2-Chloro-4-methoxy-1-nitrobenzene (CAS: 28987-59-9) typically synthesized?

2-Chloro-4-methoxy-1-nitrobenzene (CAS: 28987-59-9) is commonly synthesized by the nitration of 2-chloro-4-methoxybenzene. This is typically carried out in the presence of concentrated sulfuric acid as a catalyst. The reaction is performed at low temperature to control the rate of nitration. Selectivity and yield are influenced by the reaction temperature and the concentration of the reactants.