Compound Q&A
How is {2-[(2-Chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid (CAS: 220991-20-8) typically synthesized?
Answer
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The synthesis of {2-[(2-Chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid is typically achieved via a multi-step process involving the coupling of a 2-chloro-6-fluorophenylamine with 5-methylbenzene-1-sulfonic anhydride followed by acetylation. The reaction is catalyzed by anhydrous aluminum chloride and is carried out in dichloromethane. The yield is usually around 70-80%, and the product is purified by recrystallization from ethanol.
About
CAS No
220991-20-8
English Name
{2-[(2-Chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
Molecular Formula
C15H13ClFNO2
Molecular Weight
293.73 g/mol
SMILES
CC1=CC(=C(C=C1)NC2=C(C=CC=C2Cl)F)CC(=O)O
InChIKey
KHPKQFYUPIUARC-UHFFFAOYSA-N
Last Updated: 2025-10-16 16:48
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