Compound Q&A
How is (2E)-3-(1H-Indol-3-yl)acrylic acid (CAS: 29953-71-7) typically synthesized?
Answer
(2E)-3-(1H-Indol-3-yl)acrylic acid can be synthesized by the condensation of indole-3-carbaldehyde with acrylic acid, followed by reduction and deprotection steps. Commonly, this reaction is catalyzed by palladium-based catalysts, and the overall yield is around 70-80%. The method involves protecting groups and careful control of reaction conditions to achieve high selectivity and yield.
About
CAS No
29953-71-7
English Name
(2E)-3-(1H-Indol-3-yl)acrylic acid
Molecular Formula
C11H9NO2
Molecular Weight
187.2 g/mol
SMILES
C1=CC=C2C(=C1)C(=CN2)C=CC(=O)O
InChIKey
PLVPPLCLBIEYEA-AATRIKPKSA-N
Last Updated: 2025-10-16 16:48
