(2E)-3-(1H-Indol-3-yl)acrylic acid(CAS: 29953-71-7)

(2E)-3-(1H-Indol-3-yl)acrylic acid is a crystalline solid with a molecular weight of approximately 201.24 g/mol. It has limited water solubility and is soluble in common organic solvents like methanol and ethanol. The compound is relatively stable under normal conditions but can undergo hydrolysis in basic conditions. It is used in organic synthesis and pharmaceutical applications.

(2E)-3-(1H-Indol-3-yl)acrylic acid can be synthesized by the condensation of indole-3-carbaldehyde with acrylic acid, followed by reduction and deprotection steps. Commonly, this reaction is catalyzed by palladium-based catalysts, and the overall yield is around 70-80%. The method involves protecting groups and careful control of reaction conditions to achieve high selectivity and yield.

(2E)-3-(1H-Indol-3-yl)acrylic acid is primarily used in the pharmaceutical industry for the synthesis of bioactive compounds and in polymer science for the creation of functional materials. It also has applications in sensor technology and semiconductor manufacturing due to its chemical reactivity and ability to form stable complexes.

When handling (2E)-3-(1H-Indol-3-yl)acrylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated environment or fume hood. Spills should be cleaned up immediately and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.