Compound Q&A
How is 4-(4-Fluorophenyl)-4-oxobutanoic acid (CAS: 366-77-8) typically synthesized?
Answer
4-(4-Fluorophenyl)-4-oxobutanoic acid (CAS: 366-77-8) is commonly synthesized via the condensation of 4-fluoroaniline with butyryl chloride followed by oxidation. This process involves the use of a Lewis acid as a catalyst, such as aluminum trichloride, and proceeds with good yield and selectivity. The reaction is typically carried out under anhydrous conditions to avoid hydrolysis.
About
CAS No
366-77-8
English Name
4-(4-Fluorophenyl)-4-oxobutanoic acid
Molecular Formula
C10H9FO3
Molecular Weight
196.18 g/mol
SMILES
C1=CC(=CC=C1C(=O)CCC(=O)O)F
InChIKey
WUYWHIAAQYQKPP-UHFFFAOYSA-N
Last Updated: 2025-10-13 12:55
