4-(4-Fluorophenyl)-4-oxobutanoic acid(CAS: 366-77-8)

4-(4-Fluorophenyl)-4-oxobutanoic acid (CAS: 366-77-8) is a white crystalline solid with a molecular weight of approximately 194.15 g/mol. It has a pKa of around 3.3 and is slightly soluble in water. The compound is mildly acidic and shows reactivity typical of carboxylic acids, including esterification and amide formation. It is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

4-(4-Fluorophenyl)-4-oxobutanoic acid (CAS: 366-77-8) is commonly synthesized via the condensation of 4-fluoroaniline with butyryl chloride followed by oxidation. This process involves the use of a Lewis acid as a catalyst, such as aluminum trichloride, and proceeds with good yield and selectivity. The reaction is typically carried out under anhydrous conditions to avoid hydrolysis.

4-(4-Fluorophenyl)-4-oxobutanoic acid (CAS: 366-77-8) is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of medicinal compounds. It also has applications in polymer synthesis, where its unique chemical properties can be utilized for the development of novel materials. Additionally, it may be used in the production of sensors and semiconductors due to its electronic and optical properties.

Proper precautions should be taken when handling 4-(4-Fluorophenyl)-4-oxobutanoic acid (CAS: 366-77-8). It is recommended to use personal protective equipment (PPE), such as gloves, goggles, and a lab coat, to prevent skin and eye contact. The substance should be handled in a well-ventilated area or in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate safety measures, and the material safety data sheet (MSDS) should be consulted for detailed information on safe handling and emergency procedures.