Compound Q&A
How is Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate (CAS: 143878-29-9) typically synthesized?
Answer
Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is typically synthesized by reacting 5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid with acetamide in the presence of a coupling agent like 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The reaction is conducted at room temperature and yields a product with a high degree of purity. Selectivity and yield are around 90%.
About
CAS No
143878-29-9
English Name
Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate
Molecular Formula
C12H12ClNO4
Molecular Weight
269.68 g/mol
SMILES
CC(=O)NC1=C(C=C(C2=C1CCO2)C(=O)OC)Cl
InChIKey
LCPRNYGRYCDBOM-UHFFFAOYSA-N
Last Updated: 2025-10-08 00:58
