Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate(CAS: 143878-29-9)

Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is a white crystalline solid. Its molecular weight is approximately 324.03 g/mol. The compound is slightly soluble in water but soluble in common organic solvents such as ethanol and acetone. It is moderately reactive towards nucleophiles and can undergo various transformations in organic synthesis. It has a pKa of around 4.5, indicating it can act as a weak acid.

Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is typically synthesized by reacting 5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid with acetamide in the presence of a coupling agent like 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The reaction is conducted at room temperature and yields a product with a high degree of purity. Selectivity and yield are around 90%.

Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also used in the polymer industry for creating specialty polymers with specific properties. Additionally, it has potential applications in the sensor and semiconductor industries due to its unique chemical structure.

When handling Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up with appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.