Compound Q&A
How is 4-Methyl-3-(trifluoromethyl)benzoic acid (CAS: 261952-01-6) typically synthesized?
Answer
4-Methyl-3-(trifluoromethyl)benzoic acid can be synthesized through the Friedel-Crafts alkylation of 3-(trifluoromethyl)benzoic acid with methyl iodide. This reaction requires a Lewis acid catalyst such as aluminum chloride and typically provides good yield and selectivity. Other methods include direct synthesis from 3-(trifluoromethyl)benzoic anhydride with methylamine.
About
CAS No
261952-01-6
English Name
4-Methyl-3-(trifluoromethyl)benzoic acid
Molecular Formula
C9H7F3O2
Molecular Weight
204.15 g/mol
SMILES
CC1=C(C=C(C=C1)C(=O)O)C(F)(F)F
InChIKey
CAPKAYDTKWGFQB-UHFFFAOYSA-N
Last Updated: 2025-10-05 08:54
