Compound Q&A
How is 2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoic acid (CAS: 289686-70-0) typically synthesized?
Answer
2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoic acid is typically synthesized through a multi-step process involving the alkylation of a trifluoromethylated aromatic compound followed by esterification. Palladium-catalyzed coupling reactions and acid catalysis are commonly used. The yield is around 70-80%, and the reaction is selective due to the steric hindrance and electronic properties of the trifluoromethyl group.
About
CAS No
289686-70-0
English Name
2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoic acid
Molecular Formula
C12H10F6O2
Molecular Weight
300.2 g/mol
SMILES
CC(C)(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C(=O)O
InChIKey
ORLKRFYFNMCQIG-UHFFFAOYSA-N
Last Updated: 2025-09-23 10:23
