Compound Q&A
How is 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline (CAS: 101555-62-8) typically synthesized?
Answer
![1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline](https://static.chemtradehub.com/structs/101/101555-62-8-d59a.webp "1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline")
1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline (CAS: 101555-62-8) can be synthesized via the condensation of fluoren-9-ylmethanol with D-proline in the presence of a coupling agent such as 1-hydroxybenzotriazole (HOBt) and a base like 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). The reaction yields a high purity product with excellent selectivity and yield, making it a key intermediate in various peptide synthesis applications.
About
CAS No
101555-62-8
English Name
1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline
Molecular Formula
C20H19NO4
Molecular Weight
337.38 g/mol
SMILES
c1ccc2c(c1)-c3ccccc3C2COC(=O)N4CCC[C@@H]4C(=O)O
InChIKey
ZPGDWQNBZYOZTI-GOSISDBHSA-N
Last Updated: 2025-09-08 00:42
![1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline — JiErShengHua （ ShangHai ） Co Ltd](https://static.chemtradehub.com/suppliers/67cecb182b2de6e8e95a5951/67cecb182b2de6e8e95a5951-logo.webp){kind=logo}
![1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline — Jin Jinle (Hunan) Chemical Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce76192b2de6e8e95a464e/67ce76192b2de6e8e95a464e-logo.webp){kind=logo}
![1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline — Guangdong Wanzhang Chemical Reagent Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce43292b2de6e8e95a42fd/67ce43292b2de6e8e95a42fd-logo.webp){kind=logo}