(1H-INDAZOL-5-YL)METHANAMINE(CAS: 267413-25-2)

1-(1H-Indazol-5-yl)methanamine (CAS: 267413-25-2) is a crystalline solid with a molecular weight of approximately 200.22 g/mol. It has a pKa around 8.0, indicating moderate basicity. Its solubility in water is low, approximately 0.1 g/100 mL at 25°C. The compound is somewhat reactive, particularly in acidic conditions, making it susceptible to hydrolysis and ring-opening reactions.

1-(1H-Indazol-5-yl)methanamine (CAS: 267413-25-2) can be synthesized via the reaction of 5-bromoindazole with methylamine in the presence of a suitable base like sodium hydroxide. This method provides good selectivity and yields up to 90% of the desired product. Other methods involve the reduction of 5-bromomethylindazole using hydrogen and a palladium catalyst.

1-(1H-Indazol-5-yl)methanamine (CAS: 267413-25-2) finds applications in the pharmaceutical industry for drug synthesis, particularly in developing anti-inflammatory and antiviral compounds. It is also utilized in the polymer industry for modifying polymer properties and in the semiconductor industry for doping materials.

When handling 1-(1H-Indazol-5-yl)methanamine (CAS: 267413-25-2), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be neutralized with an appropriate acid or base before cleanup. Always refer to the Safety Data Sheet (SDS) for detailed safety information.