?-(4-CHLOROPHENYL)GLUTARIC ANHYDRIDE(CAS: 182955-12-0)

4-Chloro-4-phenyldihydro-2H-pyran-2,6(3H)-dione (CAS: 182955-12-0) is a white to off-white crystalline solid with a molecular weight of approximately 258.07 g/mol. It is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. This compound is reactive towards nucleophiles and electrophiles, making it suitable for various synthetic transformations. It exhibits good stability under normal laboratory conditions.

4-Chloro-4-phenyldihydro-2H-pyran-2,6(3H)-dione (CAS: 182955-12-0) is typically synthesized via the reaction of 4-chloro-1,3-dioxolan-2-one with phenylmagnesium bromide followed by acid work-up. The reaction is catalyzed by a strong base such as sodium hydride, and yields approximately 80-85% of the desired product. The method is selective and efficient for obtaining the compound in high purity.

4-Chloro-4-phenyldihydro-2H-pyran-2,6(3H)-dione (CAS: 182955-12-0) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those involved in anti-inflammatory and analgesic applications. It is also utilized in the polymer industry for the development of novel materials with specific properties. Additionally, it has applications in sensor technology and semiconductor manufacturing due to its unique chemical reactivity.

When handling 4-Chloro-4-phenyldihydro-2H-pyran-2,6(3H)-dione (CAS: 182955-12-0), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat to prevent skin and eye contact. Work must be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials and the area should be decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.