5-Methyl-2-(trifluoromethyl)-3-furoic acid(CAS: 17515-74-1)

5-Methyl-2-(trifluoromethyl)-3-furoic acid is a crystalline solid with a molecular weight of approximately 217.06 g/mol. It has a low water solubility, with a maximum solubility of about 0.02 g/100 mL in water at room temperature. The compound is known for its high reactivity, particularly in esterification reactions and its ability to form stable complexes with various metal ions.

5-Methyl-2-(trifluoromethyl)-3-furoic acid is typically synthesized via the condensation of methyl trifluoromethyl ketone with formic acid, followed by a Claisen rearrangement. This process often involves the use of a strong base like potassium tert-butoxide. The yield is generally high, and the reaction is known for its good selectivity.

5-Methyl-2-(trifluoromethyl)-3-furoic acid is primarily used in the pharmaceutical industry for the synthesis of certain drug molecules. It is also utilized in the polymer industry for the modification of polymers, and in the semiconductor industry for the fabrication of sensitive electronic components and sensors.

When handling 5-Methyl-2-(trifluoromethyl)-3-furoic acid, it is essential to wear appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Store the compound in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.