(1R)-1-(2-Chlorophenyl)ethanol(CAS: 120466-66-2)

(1R)-1-(2-Chlorophenyl)ethanol is a colorless liquid at room temperature with a molecular weight of approximately 169.59 g/mol. It has a solubility of about 200 mg/mL in water and is slightly soluble in ethanol. This compound is reactive towards bases and certain functional groups but stable towards light and air. It crystallizes in a monoclinic form with a melting point of about 45°C.

(1R)-1-(2-Chlorophenyl)ethanol can be synthesized via a Grignard reaction of 2-chlorophenyl magnesium bromide with (1R)-1-bromopropane. The reaction proceeds with good selectivity and moderate yield (around 70%). Commonly, catalytic hydrogenation of (1R)-1-(2-chlorophenyl)propan-1-ol is used as a step in the synthesis.

(1R)-1-(2-Chlorophenyl)ethanol is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for the production of certain polymers and plastics. Additionally, it is used in the production of sensors and as a component in some semiconductor materials.

When handling (1R)-1-(2-Chlorophenyl)ethanol, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the use of a fume hood during operations to minimize exposure. In case of spill, neutralize with an appropriate reagent and dispose of waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.