Compound Q&A
How is (1R)-1-(2-Chlorophenyl)ethanol (CAS: 120466-66-2) typically synthesized?
Answer
(1R)-1-(2-Chlorophenyl)ethanol can be synthesized via a Grignard reaction of 2-chlorophenyl magnesium bromide with (1R)-1-bromopropane. The reaction proceeds with good selectivity and moderate yield (around 70%). Commonly, catalytic hydrogenation of (1R)-1-(2-chlorophenyl)propan-1-ol is used as a step in the synthesis.
About
CAS No
120466-66-2
English Name
(1R)-1-(2-Chlorophenyl)ethanol
Molecular Formula
C8H9ClO
Molecular Weight
156.61 g/mol
SMILES
CC(C1=CC=CC=C1Cl)O
InChIKey
DDUBOVLGCYUYFX-ZCFIWIBFSA-N
Last Updated: 2025-10-20 00:35
