3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide(CAS: 778270-11-4)

3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide is a solid with a crystalline form. Its molecular weight is approximately 492.51 g/mol. This compound is slightly soluble in water but has good solubility in organic solvents such as methanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide is usually synthesized through a multi-step process, involving the reaction of 4-(trifluoromethoxy)aniline with 4-pyrimidinamine, followed by alkylation with benzoyl chloride. The reaction typically requires a Lewis acid catalyst and is conducted in an organic solvent. The yield is around 70-80%, and the product is purified by recrystallization.

3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide is primarily used in the pharmaceutical industry due to its biological activity. It can be used as an intermediate in the synthesis of drug candidates. Additionally, it may have applications in the sensor and semiconductor industries for its electronic properties.

When handling 3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide, it is crucial to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Ensure the reaction is carried out in a well-ventilated fume hood. Spills should be cleaned up with appropriate absorbent material and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.