Compound Q&A
How is 3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide (CAS: 778270-11-4) typically synthesized?
Answer
![3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide](https://static.chemtradehub.com/structs/778/778270-11-4-3a7c.webp "3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide")
3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide is usually synthesized through a multi-step process, involving the reaction of 4-(trifluoromethoxy)aniline with 4-pyrimidinamine, followed by alkylation with benzoyl chloride. The reaction typically requires a Lewis acid catalyst and is conducted in an organic solvent. The yield is around 70-80%, and the product is purified by recrystallization.
About
CAS No
778270-11-4
English Name
3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide
Molecular Formula
C18H13F3N4O2
Molecular Weight
374.32200000000006 g/mol
SMILES
C1=CC(=CC(=C1)C(=O)N)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F
InChIKey
WEVYNIUIFUYDGI-UHFFFAOYSA-N
Last Updated: 2025-10-13 17:50
![查看MedChemExpress LLC的3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide](https://static.chemtradehub.com/suppliers/67ced0fb2b2de6e8e95a67fd/67ced0fb2b2de6e8e95a67fd-logo.webp){kind=logo}
![查看HePeng （ ShangHai ） Biotechnology Co Ltd的3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide](https://static.chemtradehub.com/suppliers/67ceccf22b2de6e8e95a5e0f/67ceccf22b2de6e8e95a5e0f-logo.webp){kind=logo}
![查看ShangHaiChuangSai Technology Co Ltd的3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide](https://static.chemtradehub.com/suppliers/67cecce82b2de6e8e95a5e02/67cecce82b2de6e8e95a5e02-logo.webp){kind=logo}
![查看Jin Jinle (Hunan) Chemical Co., Ltd.的3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide](https://static.chemtradehub.com/suppliers/67ce76192b2de6e8e95a464e/67ce76192b2de6e8e95a464e-logo.webp){kind=logo}
![查看ShangHaiMaiRuiErShengHua Technology Co Ltd的3-(6-{[4-(Trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide](https://static.chemtradehub.com/suppliers/67ced3b52b2de6e8e95a6e52/67ced3b52b2de6e8e95a6e52-logo.webp){kind=logo}