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Thapsigargin(CAS: 67526-95-8)
CAS Number
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Other Suppliers for Thapsigargin
Basic Information
Molecular Formula
C34H50O12
Molecular Weight
650.76 g/mol
Physical Properties
Boiling Point
597.77°C (rough estimate)
Density
1.23±0.1 g/cm3 (20 ºC 760 Torr),
Chemical Identifiers
SMILES
CCCCCCCC(=O)O[C@@H]1[C@@H](OC(=O)C(=CC)C)C(=C2[C@H]1[C@@](C)(OC(=O)C)C[C@@H]([C@]1([C@H]2OC(=O)[C@@]1(C)O)O)OC(=O)CCC)C
InChIKey
IXFPJGBNCFXKPI-LGJGSQFISA-N
Database References
MDL Number
MFCD00083511
FAQ
Thapsigargin is a naturally occurring diterpene that acts as a potent and selective inhibitor of the endoplasmic reticulum calcium ATPase (ER-CAATPase), affecting cellular calcium homeostasis. It is used in research for studying intracellular calcium signaling and has potential therapeutic applications in cancer treatment.
Thapsigargin is primarily used in academic and pharmaceutical research for studying calcium signaling pathways. It is also explored in cancer research for its potential as a chemotherapeutic agent. Limited clinical use exists due to toxicity concerns.
Thapsigargin is considered toxic and not safe for general use due to its potential to cause severe cytotoxic effects. It should only be handled by trained professionals under strict safety protocols to prevent exposure and ensure proper disposal.
Thapsigargin should be stored in a cool, dry place away from light and heat. It should be kept in a tightly sealed container and stored at 4°C to 8°C (39°F to 46°F) to maintain stability. It is crucial to follow all safety guidelines and work in a well-ventilated area with appropriate personal protective equipment.
Safety Notice
Please verify product specifications and safety data before use. Contact the supplier for detailed safety information.
Always follow proper handling procedures
Contact Information
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