Thapsigargin(CAS: 67526-95-8)

Thapsigargin is a naturally occurring diterpene that acts as a potent and selective inhibitor of the endoplasmic reticulum calcium ATPase (ER-CAATPase), affecting cellular calcium homeostasis. It is used in research for studying intracellular calcium signaling and has potential therapeutic applications in cancer treatment.

Thapsigargin is primarily used in academic and pharmaceutical research for studying calcium signaling pathways. It is also explored in cancer research for its potential as a chemotherapeutic agent. Limited clinical use exists due to toxicity concerns.

Thapsigargin is considered toxic and not safe for general use due to its potential to cause severe cytotoxic effects. It should only be handled by trained professionals under strict safety protocols to prevent exposure and ensure proper disposal.

Thapsigargin should be stored in a cool, dry place away from light and heat. It should be kept in a tightly sealed container and stored at 4°C to 8°C (39°F to 46°F) to maintain stability. It is crucial to follow all safety guidelines and work in a well-ventilated area with appropriate personal protective equipment.