5-Phenyl-1H-pyrazole-3-carboxylic acid(CAS: 1134-49-2)

5-Phenyl-1H-pyrazole-3-carboxylic acid (CAS: 1134-49-2) is a crystalline solid with a molecular weight of approximately 182.19 g/mol. It has a pKa of 4.6, indicating acidic properties. The compound is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. It is reactive towards bases and can form salts.

5-Phenyl-1H-pyrazole-3-carboxylic acid is typically synthesized via the condensation of phenyl isocyanate and 1,3-dicarbonyl compounds. The reaction is catalyzed by acids and proceeds with good yield. The product can be purified by recrystallization from appropriate solvents.

5-Phenyl-1H-pyrazole-3-carboxylic acid (CAS: 1134-49-2) is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for modifying the properties of polymers, in sensor technology for detecting specific analytes, and in semiconductor manufacturing as a component in certain solutions.

When handling 5-Phenyl-1H-pyrazole-3-carboxylic acid (CAS: 1134-49-2), wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Use a fume hood to avoid inhalation of vapors. Handle in a well-ventilated area and follow standard laboratory safety protocols. In case of spill, neutralize with an appropriate base and dispose of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information.