3-(2-Chlorophenoxy)propanoic acid(CAS: 7170-45-8)

3-(2-Chlorophenoxy)propanoic acid is a white crystalline solid with a molecular weight of approximately 222.6 g/mol. It is slightly soluble in water and more soluble in common organic solvents like ethanol and acetone. This compound is relatively stable under normal conditions but can react with strong bases to form sodium salts. It is not flammable and has a pKa of around 4.5.

3-(2-Chlorophenoxy)propanoic acid is typically synthesized via the Friedel-Crafts acylation of 2-chlorophenol with propanoyl chloride. The reaction is catalyzed by an aluminum chloride (AlCl₃) and proceeds under reflux conditions. The yield is generally high, around 80-90%, and the product is purified by recrystallization from water or ethanol.

3-(2-Chlorophenoxy)propanoic acid is used in the pharmaceutical industry as an intermediate for the synthesis of certain herbicides and fungicides. It is also utilized in the production of sensors and polymers, where its chemical properties make it suitable for specific applications in these industries.

When handling 3-(2-Chlorophenoxy)propanoic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Store the compound in a cool, dry place and avoid contact with water or strong bases. In case of spill, do not use a dry sweep; instead, use a damp mop or cloth to clean up. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage recommendations.