(1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1H-indol-3-yl)boronic acid(CAS: 181365-26-4)

The compound (1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1H-indol-3-yl)boronic acid (CAS: 181365-26-4) is a solid with a crystalline form. Its molecular weight is approximately 352.38 g/mol. The compound is slightly soluble in water but has better solubility in organic solvents like methanol and ethanol. It is reactive towards nucleophiles and can participate in various organic reactions such as esterification and nucleophilic substitution. It has a melting point around 160-165°C.

(1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1H-indol-3-yl)boronic acid (CAS: 181365-26-4) is synthesized through a multistep process involving the protection of the indole nitrogen, esterification, and subsequent deprotection. Common methods include using tert-butyloxycarbonyl (Boc) protection for the indole nitrogen followed by esterification with a 2-methyl-2-propanol derivative. The final step involves boronation using a boronic acid ester reagent and a palladium catalyst under mild conditions. The overall yield is typically around 70-80%.

The compound (1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1H-indol-3-yl)boronic acid (CAS: 181365-26-4) finds application in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in polymer synthesis, where it can serve as a functional monomer to introduce specific chemical functionalities. Additionally, it is used in the development of new materials and sensors due to its unique structural and chemical properties.

When handling (1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1H-indol-3-yl)boronic acid (CAS: 181365-26-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using a suitable absorbent material and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal information. Ensure the compound is stored in a cool, dry place, away from direct sunlight and flammable materials.