How is (1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1H-indol-3-yl)boronic acid (CAS: 181365-26-4) typically synthesized?

(1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1H-indol-3-yl)boronic acid (CAS: 181365-26-4) is synthesized through a multistep process involving the protection of the indole nitrogen, esterification, and subsequent deprotection. Common methods include using tert-butyloxycarbonyl (Boc) protection for the indole nitrogen followed by esterification with a 2-methyl-2-propanol derivative. The final step involves boronation using a boronic acid ester reagent and a palladium catalyst under mild conditions. The overall yield is typically around 70-80%.