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Abaloparatide(CAS: 247062-33-5)
CAS Number
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Basic Information
Molecular Formula
C174H300N56O49
Molecular Weight
3960.59 g/mol
Chemical Identifiers
SMILES
O=C([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC(=O)O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(=O)O)NC([C@H](CCCNC(=N)N)NC([C@H](CCCNC(=N)N)NC([C@H](CCCNC(=N)N)NC([C@H](CC(C)C)NC([C@H](CC(=O)O)NC([C@H](CCC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@H](CC(=O)O)NC([C@H](CC1=CN=CN1)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CC1=CN=CN1)NC([C@H](CCC(=O)O)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](C)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[C@H](C(NC(C)(C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)[C@@H](C)O)=O)CC1=CN=CN1)=O)CC(C)C)=O)CCCCN)=O)=O)CC(C)C
InChIKey
BVISQZFBLRSESR-XSCWXTNMSA-N
FAQ
Abaloparatide is a cyclic pentapeptide with a molecular weight of approximately 760 Da. It is poorly soluble in water but soluble in acidic and basic aqueous solutions. This compound is stable under normal storage conditions but exhibits limited reactivity with reducing agents and heavy metals. Abaloparatide has a crystalline form and is typically stored at 2°C to 8°C to maintain its stability.
Abaloparatide is synthesized via solid-phase peptide synthesis (SPPS) using Fmoc chemistry. The synthesis involves coupling each amino acid step-by-step, followed by deprotection of the Fmoc group and cleavage from the resin. The final product is purified by RP-HPLC to ensure high selectivity and yield. Commonly used reagents include HBTU, DiPEA, and TFA for cleavage.
Abaloparatide is primarily used in the pharmaceutical industry for treating osteoporosis. It is also of interest in research for its potential applications in bone density enhancement and osteoporosis prevention. Although it has not been widely adopted in other industries like polymers or semiconductors, its unique peptide structure makes it a valuable compound for studying bone biology and related therapeutic areas.
When handling Abaloparatide, appropriate personal protective equipment (PPE) such as gloves and lab coats should be worn to prevent skin contact. Work should be conducted in a well-ventilated hood to minimize inhalation risk. Spills should be immediately cleaned up using absorbent materials and disposed of according to local regulations. For more detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS).
Safety Notice
Please verify product specifications and safety data before use. Contact the supplier for detailed safety information.
Always follow proper handling procedures
Contact Information
Contact Person
Manager Zhang
sales@takele.cn