tert-Butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperazine-1-carboxylate(CAS: 1042917-53-2)

This compound is a white solid with a crystalline form. Its molecular weight is approximately 508.51 g/mol. It is poorly soluble in water but soluble in organic solvents like DMF and DMSO. Chemically, it is stable under normal conditions but can react with strong acids or bases. It is a key intermediate in organic synthesis, particularly in boronate ester formation.

This compound is typically synthesized via a coupling reaction between 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl sulfonyl chloride and tert-butyl piperazine-1-carboxylate. The reaction is catalyzed by a palladium compound and a base such as potassium carbonate. The yield is generally around 70-80%, and the selectivity is high for the desired product.

This compound is primarily used in the pharmaceutical industry as an intermediate in the synthesis of drugs. It is also utilized in the polymer industry for the modification of polymers, and in the semiconductor industry for the development of photoresists and other materials.

Proper personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn when handling this compound. It should be stored in a cool, dry place away from heat and direct sunlight. In case of spill, it should be cleaned up using appropriate absorbent materials. Handling should be done in a fume hood to minimize exposure. Always refer to the Safety Data Sheet (SDS) for comprehensive safety information.