Ethyl 2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate(CAS: 78979-63-2)

Ethyl 2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate is a crystalline compound with a molecular weight of approximately 264.22 g/mol. It has a melting point around 175-178°C. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It is chemically reactive, particularly towards nucleophiles and reducing agents.

Ethyl 2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate is typically synthesized via the condensation of 4-nitrobenzaldehyde with ethyl 1,3-oxazole-4-carboxylate using a suitable base like sodium hydroxide. The reaction is carried out in a polar aprotic solvent such as dimethylformamide. The yield is usually around 75-85%, with high stereochemical purity.

Ethyl 2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate is used in the pharmaceutical industry for the synthesis of various bioactive molecules. It also finds applications in the polymer industry for the development of advanced materials. Additionally, it is used in the production of sensors and devices for semiconductor fabrication.

When handling Ethyl 2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate, it is essential to use personal protective equipment (PPE) such as gloves and safety goggles. Handle in a well-ventilated fume hood to avoid inhalation of volatiles. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information.