5-Fluoro-2-methylpyridine(CAS: 31181-53-0)

5-Fluoro-2-methylpyridine (CAS: 31181-53-0) is a yellowish-brown crystalline solid with a molecular weight of 133.08 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. It exhibits basic properties and is susceptible to reaction with acids. It is not highly reactive under normal conditions but can undergo substitution reactions under specific conditions.

5-Fluoro-2-methylpyridine is typically synthesized by the reaction of 2-methylpyridine with hydrogen fluoride in the presence of a fluoride source, such as calcium fluoride, under controlled conditions. The reaction yields a high purity product with good selectivity and high yield. The process requires careful control of temperature and reactant ratios to optimize product quality.

5-Fluoro-2-methylpyridine (CAS: 31181-53-0) is primarily used in the pharmaceutical industry for the synthesis of certain drugs, particularly those involving heterocyclic chemistry. It is also used in the polymer industry as an intermediate for the production of certain polymers and in the development of sensors and semiconductors where its substituent groups play a significant role.

When handling 5-Fluoro-2-methylpyridine (CAS: 31181-53-0), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled with care, using appropriate spill kits, and the area should be thoroughly cleaned. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.