Compound Q&A

How is 5-Fluoro-2-methylpyridine (CAS: 31181-53-0) typically synthesized?

Answer

5-Fluoro-2-methylpyridine
5-Fluoro-2-methylpyridine is typically synthesized by the reaction of 2-methylpyridine with hydrogen fluoride in the presence of a fluoride source, such as calcium fluoride, under controlled conditions. The reaction yields a high purity product with good selectivity and high yield. The process requires careful control of temperature and reactant ratios to optimize product quality.

About

CAS No 31181-53-0
English Name 5-Fluoro-2-methylpyridine
Molecular Formula C6H6FN
Molecular Weight 111.12 g/mol
SMILES CC1=NC=C(C=C1)F
InChIKey LXAHHHIGZXPRKQ-UHFFFAOYSA-N
Last Updated: 2025-10-13 12:55

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