6-aminopyridine-2-sulfonamide(CAS: 75903-58-1)

6-Aminopyridine-2-sulfonamide is a crystalline solid with a molecular weight of approximately 225.23 g/mol. It has a solubility of about 10 mg/mL in water and is slightly soluble in organic solvents. Chemically, it is reactive towards nucleophiles, making it suitable for various functional group transformations.

6-Aminopyridine-2-sulfonamide is typically synthesized by reacting 6-chloropyridine-2-sulfonamide with sodium azide in an aprotic solvent such as N,N-dimethylformamide (DMF) in the presence of a base like sodium hydroxide. The reaction yields the amide via an azide intermediate.

6-Aminopyridine-2-sulfonamide finds applications in the pharmaceutical industry due to its potential as a precursor for drug synthesis. It is also used in the development of sensors and in the synthesis of certain polymers and semiconductors.

Handle 6-aminopyridine-2-sulfonamide in a well-ventilated fume hood due to its potential for inhalation hazards. Wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Store it in a cool, dry place away from oxidizers and heat sources. In case of spill, clean up using appropriate safety protocols and consult the Safety Data Sheet (SDS) for further guidance.